The start of the league season was delayed until November 2020 because of the COVID-19 pandemic, and games were played behind closed doors due to Scottish Government restrictions.
On 7 January 2021 the East Region chose to suspend the season until 6 February, due to new restrictions in place because of the rising number of COVID-19 cases. On 16 March the Scottish Junior Football Association's management committee ended the season and declared all competitions null and void for a second successive season.